iso-Colchicine-d3
Product Code
TRC-C640006
CAS Number
Product Format
Neat
Molecular Formula
C22H22D3NO6
Molecular Weight
402.46
Product Categories
Anticancerous, Apoptosis, Stable isotopes, TRC, Stable isotopes
Product Type
Stable Isotope LabelledUnlabelled CAS Number
Documentation
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Product Information
Chemical Data
Analyte Name
iso-Colchicine-d3
CAS Number
1246818-69-8
Molecular Formula
C22H22D3NO6
Molecular Weight
402.46
SMILES
O=C(C([2H])([2H])[2H])N[C@@H](CC1)C2=C(C=CC(C(OC)=C2)=O)C3=C1C=C(OC)C(OC)=C3OC
Unlabelled CAS Number
518-12-7
SIL Type
Deuterium
Product Data
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Transport Restrictions
Cargo Aircaft Only Air Excepted Air Dangerous
Product Type
Stable Isotope Labelled
Product Format
Neat
Product Description
An isotopically labelled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
References: Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
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