1-(3-Chlorophenyl)piperazine-d8
Product Code
TRC-C379592
CAS Number
Product Format
Neat
Molecular Formula
C10H5D8ClN2
Molecular Weight
204.73
API Family
TrazodoneProduct Categories
TRC, Antidepressants, Impurity Reference Materials , Antidepressants, Antidepressants, 5-HT receptors, Neurotransmission, Alzheimer's, Memory, Learning and Cognition, Parkinson's, Schizophrenia, Addiction, Pain and Inflammation, Stable isotopes, Stable Isotope Labelled Analytical Standards
Unlabelled CAS Number
Purity
>95% (HPLC)
Drug Type
Antidepressants
Documentation
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Product Information
Chemical Data
Analyte Name
1-(3-Chlorophenyl)piperazine-d8
CAS Number
1189923-43-0
Molecular Formula
C10H5D8ClN2
Molecular Weight
204.73
SMILES
ClC1=CC(N2C([2H])([2H])C([2H])([2H])NC([2H])([2H])C2([2H])[2H])=CC=C1
Unlabelled CAS Number
6640-24-0
SIL Type
Deuterium
Product Data
Storage Temperature
+4°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Type
Metabolite; Stable Isotope Labelled
Product Format
Neat
API Family
Purity
>95% (HPLC)
Product Description
It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone. The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone.
References: Melzacka, M., et al.: Pol. J. Pharmacol Pharm., 32, 551 (1980), Fong, M.H., et al.: J. Pharm. Pharmacol., 34, 674 (1982), Fiorella, D., et al.: Psychopharmacology, 119, 220 (1995), Maes, M., et al.: J. Clin. Psychopharmacol., 17, 358 (1997), Bo Wen, et al.: Drug Metab. Dispos., 36, 841 (2008),
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