Product Code
TRC-H998025
CAS Number
Product Format
Neat
Molecular Formula
C15 H13 N5 O2
Molecular Weight
295.30
API Family
HymenialdisineProduct Categories
TRC, Enzyme inhibitors, Inhibits an enzyme, Impurity Reference Materials , Kinase Modulators
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Analyte Name
Hymenialdisine Analogue #1
CAS Number
693222-51-4
Molecular Formula
C15 H13 N5 O2
Molecular Weight
295.30
Accurate Mass
295.1069
SMILES
NC1=N\C(=C\2/CCNC(=O)c3[nH]c4ccccc4c23)\C(=O)N1
InChI
InChI=1S/C15H13N5O2/c16-15-19-11(14(22)20-15)8-5-6-17-13(21)12-10(8)7-3-1-2-4-9(7)18-12/h1-4,18H,5-6H2,(H,17,21)(H3,16,19,20,22)/b11-8+
IUPAC
(5E)-5-(2-amino-5-oxo-1H-imidazol-4-ylidene)-2,3,4,10-tetrahydroazepino[3,4-b]indol-1-one
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Format
Neat
API Family
The indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3+?, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations. This compound exhibits very potent inhibition of Chk2 activity in the low nanomolar range (IC50=8nM). Exhibits an increased selectivity for the checkpoint kinases over natural Hymenialdisine.
References: Sharma, V., and Tepe, J.J.: Bioorg. & Medicinal Chem. Letters, 14, 4319 (2004), Sharma, V., et al.: J. Med. Chem., 47, 3700 (2004)
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