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Imatinib

Product Code

TRC-I268023

CAS Number

152459-95-5

Product Format

Neat

Molecular Formula

C29 H31 N7 O

Molecular Weight

493.60

API Family

Imatinib, Imatinib Mesilate

Product Categories

TRC, Enzyme inhibitors, Enzyme inhibitors, API Reference Standards & Research Materials, Kinase Modulators, Kinase Inhibitors, Pharmaceutical and Veterinary Residue Reference Materials , Pharmaceutical, Veterinary Compound & Metabolite Reference Materials

Product Type

API

Alternate CAS Number

Labelled: 1092942-82-9

HPLC Purity

>95%

Price and availability

48-hour USA dispatch time
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Product Information

Product Notes

Imatinib is a 2-phenyl amino pyrimidine derivative that functions as a tyrosine kinase inhibitor, including the Bcr-AbI pathway. It is an orally bioactive anti-cancer agent used in the treatment of cancers such as chronic myelogenous leukaemia (CML) and acute lymphocytic leukaemia (ALL), all of which are Philadelphia chromosome-positive (Ph+), as well as hypereosinophilic syndrome (HES) and certain types of gastrointestinal stromal tumours (GIST).  
References
[1] Deininger MW. Milestones and monitoring in patients with CML treated with imatinib. Education Program Book; 50th ASH Conference; 2008. pp. 419–426.
[2] Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S, Zimmermann J, Lydon NB. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996. 1996;2:561–566. doi: 10.1038/nm0596-561.
[3] Deininger MW, Druker BJ: Specific targeted therapy of chronic myelogenous leukemia with imatinib. Pharmacol Rev. 2003 Sep;55(3):401-23. Epub 2003 Jul 1.
[4] Droogendijk HJ, Kluin-Nelemans HJ, van Doormaal JJ, Oranje AP, van de Loosdrecht AA, van Daele PL: Imatinib mesylate in the treatment of systemic mastocytosis: a phase II trial. Cancer. 2006 Jul 15;107(2):345-51.

Chemical Data

Analyte Name

Imatinib

CAS Number

152459-95-5

Molecular Formula

C29 H31 N7 O

Molecular Weight

493.60

Accurate Mass

493.259

SMILES

CN1CCN(Cc2ccc(cc2)C(=O)Nc3ccc(C)c(Nc4nccc(n4)c5cccnc5)c3)CC1

InChI

InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)

IUPAC

4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide

Alternate CAS Number

Labelled: 1092942-82-9

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Type

API

Product Format

Neat

API Family

Imatinib; Imatinib Mesilate

HPLC Purity

>95%

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