rac 8-Hydroxy Efavirenz
Product Code
TRC-H941825
CAS Number
Product Format
Neat
Molecular Formula
C14 H9 Cl F3 N O3
Molecular Weight
331.67
API Family
EfavirenzProduct Categories
TRC, Enzyme inhibitors, Antivirals, Antivirals and antiretrovirals, Antivirals and antiretrovirals, Anti-HIV agents, Pharmaceutical Toxicology Reference Materials
Product Type
MetaboliteAlternate CAS Number
Purity
>95% (HPLC)
Drug Type
Antivirals
Documentation
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Product Information
Chemical Data
Analyte Name
rac 8-Hydroxy efavirenz
CAS Number
205754-32-1
Molecular Formula
C14 H9 Cl F3 N O3
Molecular Weight
331.67
Accurate Mass
331.0223
SMILES
Oc1cc(Cl)cc2c1NC(=O)OC2(C#CC3CC3)C(F)(F)F
InChI
InChI=1S/C14H9ClF3NO3/c15-8-5-9-11(10(20)6-8)19-12(21)22-13(9,14(16,17)18)4-3-7-1-2-7/h5-7,20H,1-2H2,(H,19,21)
IUPAC
6-chloro-4-(2-cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
Alternate CAS Number
(S)-enantiomer: 205754-33-2
Product Data
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Type
Metabolite
Product Format
Neat
API Family
Purity
>95% (HPLC)
Product Description
A metabolite of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor.
References: Gorski, J., et al.: Biochem. Pharmacol., 47, 1643 (1994), Desta, Z., et al.: J. Pharmacol. Exp. Ther., 285, 428 (1998), Langmann, P., et al.: Eur. J. Med. Res., 7, 309 (2002), Chang, T., et al.: Drug Metab. Dispos., 31, 7 (2003),