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L-Methionine [R,S]-Sulfoximine

Product Code

TRC-M260500

CAS Number

15985-39-4

Product Format

Neat

Molecular Formula

C5 H12 N2 O3 S

Molecular Weight

180.23

Product Categories

TRC, Additional Neuro Products

Product Type

Neurochemicals

Purity

>95% (HPLC)

Price and availability

48-hour USA dispatch time
If Exact Weight packaging is selected, a certificate will be delivered with the product, which will indicate the mass of the material dispensed into the vial with a precision of up to 3 decimal places. Exceptions apply.

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Product Information

Chemical Data

Analyte Name

L-Methionine [R,S]-Sulfoximine

CAS Number

15985-39-4

Molecular Formula

C5 H12 N2 O3 S

Molecular Weight

180.23

Accurate Mass

180.0569

SMILES

CS(=N)(=O)CC[C@H](N)C(=O)O

InChI

InChI=1S/C5H12N2O3S/c1-11(7,10)3-2-4(6)5(8)9/h4,7H,2-3,6H2,1H3,(H,8,9)/t4-,11?/m0/s1

IUPAC

(2S)-2-amino-4-(methylsulfonimidoyl)butanoic acid

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Format

Neat

Purity

>95% (HPLC)

Product Description

Methionine sulfoximine inhibits both glutamine synthetase and g-glutamylcysteine synthetase. Working concentrations for inhibition of g-glutamylcysteine synthetase are 0.2-2.0 mM (52% inhibition occured at 100 mM).Methionine sulfoximine is also a toxic byproduct of nitrogen trichloride, a compound that was used to bleach unprocessed wheat flour prior to 1968. The compound has been investigated as a potential neurotoxin linked to diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson???s disease.

References: Griffith, O.W., and Meister, A.: J. Biol. Chem. 254, 7558 (1979), Willard-Mack, C.L., et al: Neuroscience, 71, 2, 589 (1996)
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