4,4'-Diisothiocyano-2,2'-stilbenedisulfonic Acid, Disodium Salt
Product Code
TRC-D460600
CAS Number
Product Format
Neat
Molecular Formula
C16 H8 N2 O6 S4 . 2 Na
Molecular Weight
498.48
Product Categories
TRC, GABA receptors, Neurotransmission, Alzheimer's, Depression, Epilepsy, Memory, Learning and Cognition, Parkinson's, Schizophrenia, Sleep, Stress and Anxiety, Stroke, Addiction, Anti-HIV agents, Pain and Inflammation, Neurology Research Chemicals and Analytical Standards, Infectious Disease Research Chemicals and Analytical Standards
Purity
>95% (HPLC)
Documentation
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Product Information
Chemical Data
Analyte Name
4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid disodium salt
CAS Number
67483-13-0
Molecular Formula
C16 H8 N2 O6 S4 . 2 Na
Molecular Weight
498.48
Accurate Mass
497.9061
SMILES
[Na+].[Na+].[O-]S(=O)(=O)c1cc(ccc1\C=C\c2ccc(cc2S(=O)(=O)[O-])N=C=S)N=C=S
InChI
InChI=1S/C16H10N2O6S4.2Na/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24;;/h1-8H,(H,19,20,21)(H,22,23,24);;/q;2*+1/p-2/b2-1+;;
IUPAC
disodium;5-isothiocyanato-2-[(E)-2-(4-isothiocyanato-2-sulfonatophenyl)ethenyl]benzenesulfonate
Product Data
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Format
Neat
Purity
>95% (HPLC)
Product Description
Stilbene disulfonates have been employed to inhibit anion transport in a large number of mammalian cell types (GABA, Cl-). Some stilbene disulfonates can bind specifically to proteins that are not anion transporters. DIDS reacts with CD4 glycoprotein on T helper lymphocytes and macrophages, blocking HIV type-1 growth at multiple stages of the viral life cycle.Fluorescence: max. Abs. l = 341, max. Em. l = 415 (in water)
References: Horie, S., et al.: Res. Comm. Chem. Pathol. Pharmacol., 79, 117 (1993) Mayinger, P. & Meyer, D.I.: EMBO J., 12, 659 (1993); Am. J. Physiol. 262, C803 (1992); J. Biol. Chem. 266, 13355 (1991).