AG-490
Product Code
TRC-A425000
CAS Number
Product Format
Neat
Molecular Formula
C17 H14 N2 O3
Molecular Weight
294.30
Product Categories
Purity
>95% (HPLC)
Documentation
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Product Information
Chemical Data
Analyte Name
AG-490
CAS Number
134036-52-5
Molecular Formula
C17 H14 N2 O3
Molecular Weight
294.30
Accurate Mass
294.1004
SMILES
Oc1ccc(\C=C(\C#N)/C(=O)NCc2ccccc2)cc1O
InChI
InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8-
IUPAC
(Z)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
Product Data
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Format
Neat
Purity
>95% (HPLC)
Product Description
A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
References: Stock, J., et al.: J. Biol. Chem., 267, 19753