text.skipToContent text.skipToNavigation
+33 (0)3 88 04 82 82

{{ addToCartData.mixPtRmWarning }}

Do you want to proceed?
{{requestQuote.productName}}; {{requestQuote.form.productCode}}

Thank you

We will respond to your enquiry shortly.

Something went wrong, please try again later.

 Bulk Order
{{ cartItemsCount }} 0
If not, click 'cancel'. You can also save this item for later.
Cancel
{{ cartItemsCount }} 0
If not, click 'cancel'. You can also save this item for later.
Cancel
Popular Regions
All Regions
+33 (0)3 88 04 82 82

Aprepitant-13C2,d2 (Major)

Product Code

TRC-A729802

CAS Number

1217676-37-3

Product Format

Neat

Molecular Formula

C2113C2H19D2F7N4O3

Molecular Weight

538.42

API Family

Aprepitant

Product Categories

TRC, Stable isotopes, Agonist & antagonist analogues, Stable isotopes, API Reference Standards & Research Materials, Additional Neuro Products, Depression, Schizophrenia, Pain and Inflammation

Product Type

Stable Isotope Labelled, API

Unlabelled CAS Number

170729-80-3

Price and availability

48-hour USA dispatch time
If Exact Weight packaging is selected, a certificate will be delivered with the product, which will indicate the mass of the material dispensed into the vial with a precision of up to 3 decimal places. Exceptions apply.
Request custom pack size quote

{{ favouriteItem.successMessage }}

View favourites

Product removed from your favourites

{{ addToCartData.mixPtRmWarning }}

Do you want to proceed?
{{requestQuote.productName}}; {{requestQuote.form.productCode}}

Thank you

We will respond to your enquiry shortly.

Something went wrong, please try again later.

Documentation

Where shall we send your requested CoA?
Part number:  {{ coaPopupData.packSize.code }}

{{ errors.first('lotNumber') }}

{{ errors.first('requestEmail') }}
LGC will use your email address only for the purposes of providing the requested document.
For information about our data processing activities, please visit our Privacy Notice.

{{ coaPopupData.serverError }}
Where shall we send your requested CoA?

Enter your email address and we'll email you the relevant CoA for lots:
{{ coaPopupData.packSize.coaSelectedLotNumbers }}

{{ errors.first('coaEmail') }}

 By entering your email address, you confirm that you give your consent to LGC to share information in connection with the product(s) above and other similar products from time to time. LGC will process your personal data in accordance with all applicable data protection rules and regulations. For information relating to LGC’s data processing activities, please visit our Privacy Policy below (see footer).
Cancel
Thank you

We will be sending the CoA to your email address  {{ coaEmailPopupData.userEmail }}

Thank you

Your request has been sent to our sales team to process.
Where shall we send your requested SDS?
Part number:  {{ sdsPopupData.packSize.code }}

{{ errors.first('selectedRegion') }}

{{ errors.first('sdsEmail') }}

LGC will use your email address only for the purposes of providing the requested document.
For information about our data processing activities, please visit our Privacy Notice.

{{ sdsPopupData.serverError }}
Thank you

Your request has been sent to our sales team to process.

Product Information

Chemical Data

Analyte Name

Aprepitant-13C2,d2

CAS Number

1217676-37-3

Molecular Formula

C2113C2H19D2F7N4O3

Molecular Weight

538.42

SMILES

O=C1N[13C]([13CH2]N2CCO[C@H](O[C@]([2H])(C[2H])C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)[C@@H]2C4=CC=C(F)C=C4)=NN1

Unlabelled CAS Number

170729-80-3

SIL Type

Carbon, Deuterium

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Type

API; Stable Isotope Labelled

Product Format

Neat

API Family

Aprepitant

Product Description

This product is deuterated at the 1 position and on the ajacent methyl. The 1 position is the benylic position of the bis(trifluoromethyl) phenyl. This compound has a mixture of 1 to 4 deuterium atoms, there is no detectable unlabeled material.Aprepitant is a structurally novel substance P neurokinin 1 (NK1) receptor antagonist. In vitro studies using human liver microsomes indicate that aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1.

References: Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Van Belle, S., et al.: Cancer, 94, 3032 (2002), Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006),
Punchout session timeout warning

Your punchout session will expire in1 min59 sec.

Select "Continue session" to extend your session.