Darunavir
Product Code
TRC-D193500
CAS Number
Product Format
Neat
Molecular Formula
C27 H37 N3 O7 S
Molecular Weight
547.66
API Family
DarunavirProduct Categories
Pharmaceutical Reference Standards, Enzyme inhibitors, TRC, Enzyme inhibitors, API Reference Standards & Research Materials, Anti-HIV agents, Antivirals and antiretrovirals, Protein kinases, Pain and Inflammation, Pharmaceutical, Veterinary Compound & Metabolite Reference Materials , Pharmaceutical and Veterinary Residue Reference Materials , Pharmaceutical Toxicology Reference Materials
Product Type
APIPurity
>95% (HPLC)
Documentation
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Product Information
Product Notes
Darunavir is a second generation HIV-1 and HCV protease inhibitor; structurally similar to amprenavir. It is an antiviral that has a high genetic barrier to resistance. Across a diverse population of HIV-1-infected subjects treated with darunavir 800 mg QD regimens, the development of darunavir resistance was rare (<0.1%).
References [1] Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003). [2] Arasteh, K., et al.: AIDS, 19, 943 (2005). [3] Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005) [4] Lathouwers, E., Wong, E., Luo, D., Seyedkazemi, S., De Meyer, S. and Brown, K. (2017) 'HIV-1 resistance rarely observed in subjects using darunavir once-daily regimens across clinical studies', HIV Clinical Trials, 18(5-6), pp. 196-204. |
Chemical Data
Analyte Name
Darunavir
CAS Number
206361-99-1
Molecular Formula
C27 H37 N3 O7 S
Molecular Weight
547.66
Accurate Mass
547.2352
Flash Point
0
SMILES
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]2CO[C@H]3OCC[C@@H]23)S(=O)(=O)c4ccc(N)cc4
InChI
InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1
IUPAC
[(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate
Product Data
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Type
API
Product Format
Neat
API Family
Purity
>95% (HPLC)
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