Product Code
TRC-B592490
CAS Number
Product Format
Neat
Molecular Formula
C18 H16 N2 O2
Molecular Weight
292.33
Product Categories
Enzyme inhibitors, TRC, Nitrogen compounds, Cytokine and Growth Factor Signalling Modulators, Additional Neuro Products, Building blocks, Neurology Research Chemicals and Analytical Standards, Cancer Research Chemicals and Analytical Standards
Purity
>95% (HPLC)
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Analyte Name
(+/-)-Blebbistatin
CAS Number
674289-55-5
Molecular Formula
C18 H16 N2 O2
Molecular Weight
292.33
Accurate Mass
292.1212
SMILES
Cc1ccc2N=C3N(CCC3(O)C(=O)c2c1)c4ccccc4
InChI
InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3
IUPAC
3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Format
Neat
Purity
>95% (HPLC)
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100uM.(±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneSelective inhibitor of nonmuscle myosin II
References: Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)
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