SANT-1
Product Code
TRC-S115000-50MG
CAS Number
Product Format
Neat
Molecular Formula
C23 H27 N5
Molecular Weight
373.49
Product Categories
Purity
>95% (HPLC)
Product Code
TRC-S115000-50MG
CAS Number
Product Format
Neat
Molecular Formula
C23 H27 N5
Molecular Weight
373.49
Product Categories
Purity
>95% (HPLC)
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Analyte Name
SANT-1
CAS Number
304909-07-7
Molecular Formula
C23 H27 N5
Molecular Weight
373.49
Accurate Mass
373.2266
SMILES
Cc1nn(c(C)c1\C=N\N2CCN(Cc3ccccc3)CC2)c4ccccc4
InChI
InChI=1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
IUPAC
(E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Format
Neat
Purity
>95% (HPLC)
A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SNAT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50=30nm in SmoA1-LIGHT2 assay).
References: Chen, J.K., et al.: Proc. Natl. Acad. Sci. USA, 99, 14071 (2002), Frank-Kamenetsky, M., et al.: J. Biol. 1, 10 (2002)
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