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H-1152 Dihydrochloride

Product Code

TRC-H011520

CAS Number

871543-07-6

Product Format

Neat

Molecular Formula

C16 H21 N3 O2 S . 2 Cl H

Molecular Weight

392.34

Product Categories

TRC, Enzyme inhibitors, Enzyme inhibitors, Kinase Modulators, Cell adhesion molecules, Pain and Inflammation

Alternate CAS Number

Free base: 451462-58-1

Purity

>95% (HPLC)

Price and availability

48-hour USA dispatch time
If Exact Weight packaging is selected, a certificate will be delivered with the product, which will indicate the mass of the material dispensed into the vial with a precision of up to 3 decimal places. Exceptions apply.
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Product Information

Chemical Data

Analyte Name

H-1152, Dihydrochloride

CAS Number

871543-07-6

Molecular Formula

C16 H21 N3 O2 S . 2 Cl H

Molecular Weight

392.34

Accurate Mass

391.0888

SMILES

Cl.Cl.C[C@H]1CNCCCN1S(=O)(=O)c2cccc3cncc(C)c23

InChI

InChI=1S/C16H21N3O2S.2ClH/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2;;/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3;2*1H/t13-;;/m0../s1

IUPAC

4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline;dihydrochloride

Alternate CAS Number

Free base: 451462-58-1

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Format

Neat

Purity

>95% (HPLC)

Product Description

ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27 mMfor PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.

References: Ikenoya, M., et al.: J. Neurochem., 81, 9 (2002), Sasaki, Y., et al.: Pharmacol. Ther., 93, 225 (2002)
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